An EGFR mutation test may be ordered by itself or as part of a panel (a series of tests to detect mutations in other genes such as KRAS, ALK and ROS1). F.A. EGFR by FISH. Treatments that target EGFR are an effective therapy for certain cancers. Receptor tyrosine kinases like EGFR transmit signals from the surface of the cell to pathways within the cell. Reference ranges are the values expected for a healthy person. The detected mutations are the most common acquired mutations in this gene in cancer, and are associated with sensitivity to drugs that inhibit the tyrosine-kinase activity of the EGF receptor protein. ARUP's Guide to Clinical Laboratory Testing [On-line information]. Check, W. (2004 January). Consensus for EGFR mutation testing in, Cagle PT et al. The request system should specify what is required to perform the EGFR mutation test so that the appropriate sample and information is provided.1. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/61247. PDF available for dowload at http://www.arup-lab.com/media/pdf/testing/tech_bulletins/egfr_apr04.pdf. You may have been directed here by your lab's website in order to provide you with background information about the test(s) you had performed. Impact of Epidermal Growth Factor Receptor Expression on Survival and Pattern of Relapse in Patients with Advanced Head and Neck Carcinoma. ® EGFR Mutation Test v2 test results using plasma specimens for the presence of EGFR exon 19 deletions or L858R mutations are eligible for treatment with TARCEVA® (erlotinib). These tests are not helpful for identifying patients with lung cancer who may benefit from EGFR-targeted tyrosine kinase inhibitor therapy. Patients with positive cobas ® EGFR Mutation Test v2 test results using plasma specimens for the presence of EGFR exon 19 deletions or L858R mutations are eligible for treatment with TARCEVA ® (erlotinib). A new sample of tumor tissue, or sometimes a blood sample, is required to determine whether the cancer has acquired new mutations that make it resistant to the current treatment. You will need to return to your lab's website or portal, or contact your healthcare practitioner in order to obtain your test results. Grody, W. (2007 January 30). (2004). Available Online at http://www.forbes.com/2004/04/29/cx_rl_0429cancer_print.html. (2007 July 25). While accuracy of laboratory testing has significantly evolved over the past few decades, some lab-to-lab variability can occur due to differences in testing equipment, chemical reagents, and techniques. Results: In the overall population, we identified 227 KRAS (25%) and 222 EGFR (20%) mutations. TKIs can block the action of EGFR to inhibit cancer cell growth. For diagnosis of your tumor, you will need a conventional tissue biopsy. ASCP 2006: Applications of Molecular Methods in Surgical Pathology CME/CMLE. Accessed on 1/31/2018. 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